Applications

Applications

Challenges that Biolojic can solve

– Design functional antibodies for difficult epitopes (i.e. cryptic/hidden, activation induced)
– Design binders of shared epitopes across a few members of the family (pan-family
or broadly neutralizing antibodies)
– Design binders for a unique epitope to one member (specific family member)
– Make existing antibodies species cross-reactive
– Target mutant but not the WT targets (escape mutations)
– Improve poor antibodies that have failed traditional affinity maturation
– Avoid immuno-dominant epitopes
– Introduce bi-specificity or selective cross reactivity into an existing antibody
– Design bi-specific and dual-specific antibodies
– Design a specific mechanism of action (agonists, antagonists, reverse agonists)
– Design biologically active binders of difficult targets (e.g. GPCRs, ion channels)